Many patients with orofacial pain disorders require pharmacologic intervention. Patient outcomes are dependent on appropriate medication selection, adverse effect profile, and method of administration. This course will review the top 10 medications used for arthrogenous, myogenous, and neuropathic conditions as well as the various topical, oral and injectable medications. We will discuss choosing the appropriate medications for arthrogenous, myogenous, and neuropathic disorders and examine the mechanism of action of pharmacotherapeutics for orofacial pain and their common adverse effects.