Oral health is essential for overall health, but oral inflammation management procedures have not changed significantly in 70 years. To improve oral health and reduce systemic health risks, the dental community must implement new, innovative, and evidence-based practices. Join this thought-provoking discussion on the systematic approach to addressing oral inflammation and its impact on overall health. We will review current scientific literature, identify clinical implications, and discover new evidence that affects our clinical decision-making strategies regarding comprehensive patient care.