Ever had a herpetic lesion or apthous ulcer? They hurt! What is the antibiotic of choice in healthy, ambulatory patients who have an orofacial infection? If a patient is allergic to penicillin can a practitioner use a cephalosporin? What are the most recent recommendations for antibiotic prophylaxis in patients who have an orthopedic prosthesis or to prevent SBE? This discussion will include how to use selected antifungal, antiviral, and antibiotic medications more effectively to treat patients with orofacial infections.