HPV-related oropharyngeal cancer, or HPV-OPC, now represents over 70 percent of all oropharyngeal cancers, with cases increasing by 30 percent annually. Because high-risk HPV strains are often transmitted through oral sex and can be detected in saliva, dental professionals play a vital role in screening, education and prevention. This course reviews current research, screening protocols, vaccine updates, salivary diagnostics and communication strategies to address sensitive topics confidently, empowering providers to detect disease early and promote patient health through prevention-focused care.