One in six dental patients experience orofacial pain. Most often, this pain presents as a toothache. However, not all toothaches are caused by an odontogenic source. Unfortunately, these types of pain sources can be perplexing for both the patient and the dentist. This course will provide a comprehensive review of non-odontogenic sources of tooth pain. Attendees will learn how to differentiate between odontogenic and non-odontogenic toothaches, the appropriate examination methods, diagnostic tests, and management of non-odontogenic toothaches.