According to recent studies, about 1 in 12 adults in America have an active substance use disorder. In addition, about 30% of adults misuse substances without showing any outward signs of a disorder. Research indicates substances have a detrimental effect on one’s health, including their oral health. The dental professional can play a vital role in supporting patients with substance use disorder. Oftentimes dental providers are the health care professional spending the most one-on-one time with patients. Therefore, they are in a position to screen and advise patients on this issue. With the right skills and confidence, dental professionals can serve as the first line of defense against risky substance use.