This course is designed to guide the attendee through the differential diagnosis, treatment, and management of commonly encountered oral soft tissue growths and ulcers and identify when to biopsy. We will address the differential diagnoses of white lesions including leukoplakia and lichen planus and red lesions including erythroplakia and geographic tongue. Emphasis on the clinical presentation of oral dysplasia or early cancer will be illustrated. Biopsy techniques including direct immunofluorescence will be reviewed. Differentiating oral ulcers based on clinical presentation, duration and location will be discussed, specifically, oral herpes and aphthous ulcers. We’ll review diagnosis and treatment options for burning mouth/tongue syndrome and other vesiculo-erosive conditions.