Although most research in preventive dentistry has been done with children, this presentation will focus on the large number of high-risk seniors. A research-driven approach to the prevention of caries, periodontal diseases, oral cancer, denture stomatitis, erosion, abrasion, attrition, candidiasis, gingival hyperplasia, viral and ulcerative diseases will be presented. Chemotherapeutic agents (including SDF) will guide you in the proper use of products. The latest recommendations from the ADA will be examined.